The Effects of Vitamin D Deficiency and Benefits of Supplementation

by Logan Swisher, PT, DP

Introduction

Vitamin D (VITD) is important in bone health, skeletal muscle growth, inflammatory modulation, immune and cardiopulmonary function. VITD can also interact with extraskeletal tissues to modulate injury recovery and influence of the risk of infections. It is estimated that 1 billion people in the world currently have VITD deficiency and that number is on the rise. The major cause for the VITD deficiency is the lack of awareness in the population that sun exposure is the main source of vitamin D. In relation to food sources of VITD, it is difficult to obtain vitamin D through the diet because very few foods naturally contain the vitamin, exceptions being eggs, cheese and fatty fish such as salmon, sardines, herring.

How is Vitamin D Metabolized?

Vitamin D is an organic compound in food needed in small amounts for growth and good health but the human requirement can actually be met entirely through synthesis in the skin upon exposure to sunlight. The ultraviolet-B (UVB) radiation in sunlight converts to D3 and the newly synthesized vitamin D (as well as vitamin D obtained from the diet) is escorted to the liver. In the liver, vitamin D is rapidly converted to 25(OH)D, the main storage form. Further activation in the kidney is driven by parathyroid hormone (PTH) when blood calcium and/or phosphate concentrations fall below the normal range.

Benefits of Vitamin D

Sufficient levels of Vitamin D provide multiple musculoskeletal benefits such as: increased muscle protein synthesis, ATP concentration, strength, jump height and velocity, exercise capacity, physical performance, decrease muscle protein degeneration and reverse myalgias. It is also well known that vitamin D plays an important role in bone health, fracture prevention and reducing the risk and impact of diabetes, multiple sclerosis, certain cancers, cardiovascular diseases and hypertension, cerebrovascular diseases, infectious diseases, asthma, depression, and other autoimmune and chronic inflammatory disorders.

How much Vitamin D do you need?

In order to properly assess levels of Vitamin D, blood levels of total 25-hydroxy vitamin D (25(OH)D) must be taken. There are studies which suggest that a value of 25(OH)D >30 ng/mL should be considered as acceptable for maintaining bone health and reducing the risk of fracture in healthy young people and adults, while others suggest that necessary levels should be set at >40 ng/mL. 25(OH)D levels above 40 ng/mL are required for fracture prevention, including stress fractures. Optimal musculoskeletal benefits occur at 25(OH)D levels above the current definition of sufficiency (> 30 ng/mL) with no reported sports health benefits above 50 ng/mL. The Institute of Medicine recommended dietary allowance (RDA) of vitamin D for the US and Canada is 600 IU for children and adults under 70 years of age and 800 IU for those over 70 years old. It is important that you discuss this with your primary care provider prior to taking any Vitamin D supplements.

 References

De la Puente Yagüe M, Collado Yurrita L, Ciudad Cabañas MJ, Cuadrado Cenzual MA. Role of Vitamin D in Athletes and Their Performance: Current Concepts and New Trends. Nutrients. 2020 Feb 23;12(2):579. doi: 10.3390/nu12020579. PMID: 32102188; PMCID: PMC7071499.

Shuler FD, Wingate MK, Moore GH, Giangarra C. Sports health benefits of vitamin d. Sports Health. 2012 Nov; 4(6):496-501. doi: 10.1177/1941738112461621. PMID: 24179588; PMCID: PMC3497950.

Treating Your Low Back Pain: But my MRI says….

By Joseph Holmes, PT, DPT, CDN, FNCP

The likelihood that any adult in the United States will experience some form of low back pain each year is 1.5%-36%. Moreover, about 25% of adults report having at least 1 day of low back pain in the past 3 months (1). There are many factors that affect the likelihood of this happening (2). Most people assume that when back pain occurs, whether it is aggravating or debilitating, an x-ray or MRI is needed and that they should be prescribed muscle relaxers and/or painkillers. However, updated guidelines from the American College of Physicians recently announced that, “doctors should avoid prescribing opioid painkillers for relief of back pain and suggest that before patients try anti-inflammatories or muscle relaxants, they should try alternative therapies like exercise, acupuncture, massage therapy or yoga” (3). Furthermore, previous guidelines stated that imaging, such as an MRI, demonstrated no value to the patient and can also lead to worse and more costly outcomes. Thus, imaging should only be prescribed if severe neurological symptoms are present (4).

To address the growing demand for treatment of the increasing number of people who have low back pain, physical therapists have created the Low Back Pain clinical practice guidelines. These are rigorous guidelines which synthesize all the available evidence on low back pain assessment, diagnosis, and intervention/treatment. The most recent version of the guidelines, published in 2012 by the American College of Physicians, stated that people need an active intervention in order to show the quickest improvement in healing their pain and returning to normal function. Often low back pain will heal on its own eventually, that is, if the proper actions are taken.

Physical therapists, guided by the clinical practice guidelines, use the most up to date information to help the approximately 30-50 million Americans who experience low back pain every year. Because most back pain cannot be directly associated with a specific cause of injury, this leads to many inaccurate findings on MRIs, CT scans, and X-rays, including people with no back pain symptoms whatsoever being diagnosed with “abnormal” findings of the lumbar spine 32% of the time (5). Thus, the best available evidence supports a classification approach that de-emphasizes the importance of identifying specific anatomical lesions after red flag screening is completed. There is still so much that experts do not understand about low back pain. What we do know is that the best physical therapists will diagnose and treat your back pain based on your individualized symptoms and reported limitations.  We will work with you to create goals and interventions that will help to alleviate your pain and allow you to return back to your regular function.

The 2012 Low Back Pain Clinical Practice Guidelines utilized the four treatment-based classifications to categorize low back pain that were created in 2007 (6). They are as follows:

  • Manipulation (based on strong evidence from the Flynn et al Clinical Prediction Rule):
    • A person is a great candidate for manipulation if they meet most of these criteria:
      • No symptoms below your knee
      • Recent onset of symptoms less than 16 days
      • Low fear avoidance based off a validated questionnaire (FABQ-work <19)
      • At least 1 stiff/hypomobile segment of the lumbar spine
      • At least 35 degrees of internal rotation, a measurement of hip rotation, in 1 hip
    • Stabilization:
      • A person is a great candidate for the stabilization if they meet most of these criteria:
        • <40 years old
        • Post-partum or straight leg raise >90 degrees
        • Positive prone instability test
        • Poor rhythm of bending over and flexing the spine
      • Specific Exercise, Centralization, or Directional Preference:
        • A person is a great candidate for specific exercise if they meet most of these criteria:
          • Symptoms below the buttock
          • Older age
          • Preference to bend over in to flexion or back into extension to get relief
        • Traction:
          • A person is appropriate for intermittent traction if they meet most of these criteria:
            • Signs and symptoms of nerve root compression, weakness, or crossed SLR
            • Peripheralization of symptoms or worsening of symptoms in the legs with both bending forwards and backwards

            After your physical therapist categorizes your clinical presentation into one of these four categories, your individualized program will be created using the support of the best evidence available combined with years of clinical expertise. Additionally, the low back pain clinical practice guideline recommends the following interventions which best match your treatment-based classification (7). A is considered the best evidence and E is the worst evidence.

            • (A): Manual therapy such as soft tissue mobilization, core stabilization, directional preference, and progressive endurance training and exercise.
            • (B): Patient Education: Do NOT increase patient’s fear or perceived threat
            • (C): Flexion or bending forward for lumbar stenosis: people with lumbar stenosis should be performing strengthening, stretching, and increased endurance activities
            • (D): Lumbar traction: If a person is classified in to the above traction classification, then traction can be slightly helpful, otherwise it is of no benefit
            • Not listed: no grade or recommendation was made towards heat, ice, electrical stimulation, or dry needling

            Physical Therapy First

            At Physical Therapy First, you are provided with more individualized time in your initial evaluation and treatment sessions than with any other provider in the region. Our physical therapists perform 60 minute 1-on-1 initial evaluations and all follow up sessions are 1-on-1 for 60 minutes with your physical therapist. We provide the best care in the region with the highest qualified clinicians. Call or email any of our four locations in the Greater Baltimore area to set up your appointment today.

            References:

            1. Deyo RA , Mirza SK , and  Martin BI . Back pain prevalence and visit rates: estimates from U.S. national surveys, 2002. Spine (Phila Pa 1976). 2006;31:2724-7. [PMID: 17077742]
            2. Hoy D, Brooks P, Blyth F, Buchbinder R. The Epidemiology of low back pain. Best Pract Res Clin Rheumatol. 2010;24:769-781. http://dx.doi.org/10.1016/j.berh.2010.10.002
            3. Amir Qaseem, Timothy J. Wilt, Robert M. McLean, et al. Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians. Ann Intern Med.2017;166:514-530. [Epub ahead of print 14 February 2017]. doi:10.7326/M16-2367
            4. Chou R, Qaseem A, Snow V, et al. Diagnosis and Treatment of Low Back Pain: A Joint Clinical Practice Guideline from the American College of Physicians and the American Pain Society. Ann Intern Med.2007;147:478-491. [Epub ahead of print 2 October 2007]. doi:10.7326/0003-4819-147-7-200710020-00006
            5. Savage RA, Whitehouse GH, Roberts N. The relationship between the magnetic resonance imaging appearance of the lumbar spine and low back pain, age and occupation in males. Eur Spine J. 1997;6:106-114.
            6. Fritz, JM, Cleland, JA, Childs, JD. Subgrouping patients with low back pain: evolution of a classification approach to physical therapy. J Orthop Sports Phys Ther. 2007;37:290–302.
            7. Delitto A, George SZ, Van Dillen L, Whitman JM, Sowa G, Shekelle P, Denninger TR, Godges JJ. Low Back Pain: Clinical Practice Guidelines. J Orthop Sports Phys Ther 2012;42(4):A1-A57. doi:10.2519/jospt.2012.42.4.A1

Blood flow restricted exercise for athletes: A review of available evidence

by Stephanie Beatty, SPT

Introduction: What is blood flow restriction and how does it work?

– Blood flow restriction (BFR) involves the placement of a cuff around an arm or leg in an effort to prevent venous return, or the flow of blood through the veins of the limb back to the heart, while still allowing blood to flow from the heart to the limb through the arteries. By occluding blood flow, lighter weights and lower exercise intensities can be used to achieve similar benefits to those that would be achieved with higher intensity exercise without blood flow restriction. While the exact mechanisms are unclear, when used during exercise, blood flow restriction is thought to induce both short- and long-term changes in muscle characteristics, muscular development, and overall performance. Blood flow restriction is commonly used in older patients, patients recovering from an injury, and other patients who are unable to tolerate exercising with higher loads, but it has been shown to be beneficial to athletic populations as well. The objective of this literature review was to assess the evidence of acute and longer-term adaptive responses to exercise with BFR in trained athletes.

Methods

– The authors in this literature review identified twelve papers that fit their established inclusion criteria and assessed acute and adaptive responses to different types of exercise with BFR in various athletic populations, including track and field athletes, football players, netball players, rugby players, basketball players, and ice hockey players.

Summary of Evidence

– Training responses to BFR combined with low-load resistance exercise included:

o Decrease in metabolic stress imposed on muscles during exercise
o Increase in growth hormone concentration with a decrease in the concentration of chemical indicators of muscle damage
o Increase in squat, bench press, and leg press 1-RM (depending on activity during which BFR was applied)
o Decrease in sprint and acceleration times
o Increase in muscle strength
o Increase in muscle endurance
o Increase in muscle torque production
o Increase in muscle cross-sectional area and girth
o Improved performance on sport specific physical assessments

– Training responses to BFR combined with moderate-load resistance exercise included:

o Increase in squat and bench press 1-RM
o Improved jump and sprint performance
o Increase in levels of testosterone and cortisol
– Training responses to BFR combined with low-intensity cardio included:
o Improved aerobic capacity and anaerobic power
– It should be noted that many of these studies reported that training adaptations were sport specific and varied by athletic population (i.e. endurance-dominant athletes experienced different adaptations than strength-dominant athletes). Additionally, low intensity exercise with BFR has not been shown to produce significant changes in connective tissues. For this reason, authors stressed the importance of combining low-intensity BFR exercise training with high-intensity strength training without BFR to allow proportional changes to occur in the tendons and reduce the risk of tendon injury.

Conclusion and Clinical Applications:

– BFR can be used with low-intensity resistance training to produce changes in muscle and improvements in performance in higher-level athletes.
– Exercise training with BFR should be sport specific.
– It is important to combine low-intensity BFR training with high-intensity training without BFR to continue to stress the connective tissues and reduce the risk of tendon injury.
– BFR with low-intensity exercise can be used as an adjunct during de-loading weeks or during recovery from injury.
– Exercises done with BFR should still be progressed for continued improvements.

At Physical Therapy First, we treat a variety of patient populations including well-trained athletes, recreationally active patients, post-operative patients, and deconditioned patients, all of whom blood flow restriction has been shown to help. We offer individualized therapeutic exercise and home exercise routines. During your evaluation, your therapist can further discuss blood flow restriction and how it may help you recover from an injury and improve your function.

Reference:

Scott BR, Loenneke JP, Slattery KM, Dascombe BJ. Blood flow restricted exercise for athletes: A review of available evidence. Journal of Science and Medicine in Sport. 2016; 19(5):360-367. doi:10.1016/j.jsams.2015.04.014

Sleep Hygiene Tips and Tricks

Gabrielle Herman, PT, DPT, CMPT

 The three pillars of health include diet, exercise, and sleep. Optimizing all three is critical to exercise recovery as well as overall health and well-being. Ignoring one pillar often causes the other two pillars to suffer. For example, someone that is sleep deprived may perform poorly in exercise or begin to crave unhealthy foods. These negative effects of sleep deprivation must be addressed regularly by sports medicine providers as well as general practitioners as there are clear negative effects of sleep deprivation on performance in athletes such as accuracy, reaction time, endurance, submaximal strength as well as cognitive functions including judgement and decision-making.

 Sleep Deprivation in Elite Athletes

High level athletes are known to get less total sleep than non-athletes due to demanding training and competition schedule and travel and time zone changes. Stress and anxiety before an upcoming game or match may also hinder an athlete from getting a healthy sleep. In addition to this, the significant increase in smartphone and electronic devices further interrupt sleep schedules with possible negative impacts on melatonin production from blue-light emissions.

Negative Effects of Sleep Deprivation

  • Neurocognitive, metabolic, immunologic, and cardiovascular dysfunctions are shown in general population
  • Physical effects in athletes:
  • Decreased running performance
  • Decreased muscle glycogen concentration
  • Reduced submaximal strength
  • Decreased soccer kicking skills
  • Decreased tennis serve accuracy
  • Decreased time to exhaustion

Positive Effects of Sleep Extension

  • Restoration of sleep and sleep extension can improve the following
  • Sprint times
  • Tennis serve accuracy
  • Swim and kick stroke efficiency and swim spring
  • Basketballs shooting accuracy
  • Time to exhaustion
  • Psychomotor vigilance tasks, alertness, vigor, and mood
  • Decreased sleepiness and fatigue
  • Newer studies demonstrate a nap the day following a night of sleep deprivation may be beneficial
  • A new concept of “banking sleep” which is a sleep extension prior to a night of sleep deprivation in a pilot study improved motor performance
  • Most studies agree upon increasing sleep by 2 hours with the goal of 9 hours for elite athletes
  • Future research is needed to further detail the benefits of banking sleep

Top Ten Recommendations for Healthy Sleep Hygiene

  1. Don’t go to bed until you are sleepy
  2. Regular bedtime routine/rituals help you relax and prepare body for sleep
    • Warm bath
    • Reading a book
  3. Try to get up at the same time every morning (including weekends and holidays)
  4. Try to get a full night’s sleep every night and avoid daytime naps (if you must nap, limit to 1 hour and avoid nap after 3 pm)
  5. Use the bed for sleep and intimacy only; not for any other activities including TV, phone use, or laptop
  6. Avoid caffeine if possible, if must use, avoid after lunch
  7. Avoid alcohol is possible, if must use, avoid right before bed
  8. Don’t smoke or use nicotine, ever
  9. Consider avoiding high-intensity exercise right before bed
  10. Make sure bedroom is quiet, as dark as possible, and a little on the cool side rather than warm

Additional Sleep Hygiene Recommendations

  1. Avoid blue light emitted from screens at least 2 hours before bed
  2. Get bright, natural sunlight upon awakening – some suggest at least a 10,000 lux lamp if you cannot get natural sunlight
  3. Don’t hit the snooze button, it does not improve sleep quality
  4. If you have difficulty waking up, some suggest a dawn-simulator alarm clock
  5. If you must use a computer at night, consider installing blue-light reducing software or wear blue-light blocking glasses
  6. Higher Carbohydrate foods at night may actually improve sleep, as well as high protein including tryptophan. High fat intake may disrupt sleep. Inadequate total caloric intake during the day may impair sleep at night.
  7. Topical magnesium (salt bath, topical mineral oil, or oral magnesium may help if you are deficient
  8. Melatonin naturally occurring in foods (Tart cherry juice, raspberries, goji berries, walnuts, almonds, tomatoes) may potentially improve sleep, but avoid artificial melatonin supplements
  9. Don’t fall asleep to the T.V. Sleep studies show you frequently wake up during the night and have poor quality sleep.
  10. Herbal supplements are largely unknown with potential serious side effects, and may be on the USADA-prohibited list or result in positive banned substance test for athletes
  11. Consider reducing fluid intake before bed so you don’t get up to go to the bathroom (Only if you maintain enough hydration during the day)
  12. Cooling body temperature may improve sleep. Some suggest keeping the room between 60-70 degrees; however, keep hands and feet warm
  13. Check your mattress – it may be too old and have allergens (most last 9-10 years)
  14. Recovery from exercise should not only focus on muscle recovery. Reducing mental fatigue is just as important for health sleep. Reduce external stressors in your life.

References:

Vitale, K. C., Owens, R., Hopkins, S., Malhotra, A., Sleep Hygiene for Optimizing Recovery in Athletes: Review and Recommendations. Int J Sports Med. August 2019: 40(8): 535–543. doi:10.1055/a-0905-3103

Carpal Tunnel Syndrome-2019 Clinical Practice Guidelines for Hand Pain and Sensory Deficits

By Joseph Holmes, PT, DPT, FNCP

A leading group of physical therapists gathered over a couple year period to review all the most up to date literature on the conservative treatment of carpal tunnel syndrome (CTS). CTS is defined as having a compression of the median nerve going through the carpal tunnel of the wrist, and reproduces pain, numbness, or weakness in the thumb, index, middle, and half of the ring finger all on the palm side of the hand (Wipperman, 2016). 3.8% of the population experiences carpal tunnel syndrome annually, with the prevalence higher among women than men, most common in 40–60-year-olds, and as expected increases in frequency with an increased presence of the following co-morbidities (Ibrahim et al, 2012):

  • Smoking
  • Diabetes
  • Personal history of carpal tunnel syndrome
  • Family history of carpal tunnel syndrome
  • Work activities which put frequent force or vibration through the wrist such as typing

CTS can be treated surgically with successful outcomes, but also can be intervened with on a conservative basis, such as with physical therapy. I will summarize the latest evidence on how your physical therapists at Physical Therapy First will use the latest research and evidence to help you recover from your carpal tunnel syndrome, with guidance from the 2019 Clinical Practice guidelines for Carpal Tunnel Syndrome (Erickson et al, 2019).

The evidence to support these recommendations for the diagnosis and treatment of your carpal tunnel syndrome is based on a criterion of strong to very weak or poor evidence. The criteria are described in further detail below:

Image from the CTS: CPG, page 6.

 Diagnosis

The clinical practice guidelines recommend using the following criterion for proper diagnosis of carpal tunnel syndrome. Your physical therapist at Physical Therapy First will use the most up to date and accurate criterion to provide you with the best information available regarding your diagnosis. The CPG recommends using monofilament testing to assess a person’s response to the feeling of light touch, and the ability to discriminate that touch throughout various parts of your palm and hand. Your physical therapists will also assess the following risk factors which may put you at higher risk of having Carpal Tunnel Syndrome:

  • Age >45
  • Does shaking your hand relieve your symptoms?
  • Do you have loss of sensation in your thumb?
  • Is the depth of your wrist >.67% the size of the width of your wrist?
  • And upon completing the subjective Boston Carpal Tunnel Questionnaire-Symptom Severity Scale, do you score greater than 1.9? See the BCTQ-SSS, below:

Image courtesy of Levine et al. 1993, the creators of the BCTQ-SSS.

After completion of these 5 risk factors, noting positives on 3 of the 5 leads to an accurate diagnosis of Carpal Tunnel Syndrome. Next, the clinician will perform multiple hands on manual reproductive tests of the wrist (Phalen’s, Tinnel’s, and the Carpal Tunnel Compression Test) to see if compression or palpation of the carpal tunnel reproduces your carpal tunnel symptoms. All of the above diagnostic criteria are rated as ‘A’ or ‘B’, signifying good or very good evidence in support of their performance and accuracy.

Examination

There is either poor evidence or no evidence in support of the following examination criteria to test for Carpal Tunnel Syndrome:

  • Lateral Pinch Strength
  • Grip strength: Not accurate after surgery, but good examination tool non-surgical
  • Conflicting evidence for testing pinch tip strength of the thumb and first and second fingers
  • Little or conflicting evidence regarding sensory discrimination, threshold, or vibration testing

Interventions

The following interventions are recommended with strong (A), moderate (B) or weak (C) evidence for Carpal Tunnel Syndrome:

  • A neutral positioned wrist splint to be worn at night for short term relief
  • Therapeutic exercise including stretching for mild to moderate CTS
  • Manual therapy (joint mobilizations, stretching) to the cervical spine and upper extremity for people with mild to moderate CTS
  • A trial of electrical stimulation for short term pain relief
  • A trial of superficial heat for short term pain relief

Physical Therapists should not use the following treatment interventions due to poor or conflicting evidence for their effectiveness:

  • Low level laser
  • Iontophoresis
  • Thermal or Non-thermal ultrasound

 The physical therapists at Physical Therapy First look forward to assisting you in conservative strategies to relieve your carpal tunnel pain and subsequent dysfunction, guided by the best evidence available. Physical Therapy First provides the highest quality care in the Greater Baltimore region with 1 on 1 treatment sessions with your physical therapists for 1 hour. Contact any of our offices (Roland Park, Timonium, Clarksville, or Rosedale today to set up your 1 on 1 consultation with the area’s best physical therapists.

1) Wipperman J, Goerl K. Carpal Tunnel Syndrome: Diagnosis and Management. Am Fam Physician. 2016 Dec 15;94(12):993-999. PMID: 28075090.

2). Ibrahim I, Khan WS, Goddard N, Smitham P. Carpal tunnel syndrome: a review of the recent literature. Open Orthop J. 2012;6:69–76.

3) Erickson M, Lawrence M, Jansen CWS, Coker D, Amadio P, Cleary C. Hand Pain and Sensory Deficits: Carpal Tunnel Syndrome. J Orthop Sports Phys Ther. 2019 May;49(5):CPG1-CPG85. doi: 10.2519/jospt.2019.0301. PMID: 31039690.