by John Baur, PT, OCS, FAAOMPT
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that affects the colon and rectum. It is characterized by symptoms such as abdominal pain, diarrhea, and rectal bleeding. While the exact cause of UC is unknown, it is believed to be related to an imbalance in the gut microbiota and inflammation. Probiotics are live microorganisms that can provide health benefits when consumed in adequate amounts. Bacillus spp. spores are a type of probiotic that have been shown to modulate the gut microbiota and improve overall health. In this report, we will discuss a study that investigated the effects of a probiotic containing Bacillus spp. spores, amino acids, and immunoglobulins on a rat model of UC.
Methods
The study used a rat model of UC induced by dextran sulfate sodium (DSS). The rats were divided into four groups: a control group, a DSS group, a DSS group treated with the probiotic, and a DSS group treated with mesalazine, a standard treatment for UC. The probiotic contained Bacillus spp. spores, amino acids, and immunoglobulins.
The rats were treated with the probiotic or mesalazine for a period of 14 days. The severity of UC was assessed by measuring body weight, stool consistency, and rectal bleeding. The inflammatory response was assessed by measuring levels of inflammatory cytokines in the colon tissue.
Results
The study found that treatment with the probiotic containing Bacillus spp. spores, amino acids, and immunoglobulins exerted protective effects on the rat model of UC. The probiotic significantly reduced the severity of UC, as evidenced by improvements in body weight, stool consistency, and rectal bleeding. The probiotic also reduced the inflammatory response, as evidenced by reductions in levels of inflammatory cytokines in the colon tissue.
Conclusion
The study suggests that treatment with a probiotic containing Bacillus spp. spores, amino acids, and immunoglobulins can exert protective effects on a rat model of UC. The probiotic reduced the severity of UC and the inflammatory response, suggesting that it could be a promising treatment option for UC. Further research is needed to confirm these findings in human clinical trials, but the study provides a promising avenue for future research in the field of probiotics and UC treatment.
Physical Therapy First recognizes the importance staying well-informed with the latest health and wellness topics that affect our patients. Megasporebiotic made by Microbiome Labs (microbiomelabs.com) is the first spore-base probiotic with research which supports it use for Ulcerative colitis (UC) and many other health conditions.
Reference
Probiotic Bacillus Spores Together with Amino Acids and Immunoglobulins Exert Protective Effects on a Rat Model of Ulcerative Colitis. Catinean A, Neag MA, Krishnan K, Muntean DM, Bocsan CI, Pop RM, Mitre AO, Melincovici CS, Buzoianu AD. Nutrients. 2020 Nov 24;12(12):3607. doi: 10.3390/nu12123607.